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In contrast with mouse thymocytes, mouse ES cells contain increased levels of total genomic H3K4me3 and have higher H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 forty six In agreement with this, world decreases in H3K4me3 levels occur throughout retinoic acid (RA)-induced differentiation of mouse ES cells 47 As well as, there are dynamic modifications in H3K4me3 profiles at particular units of genes during ES cell differentiation.

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